Table 2.

Univariate and multivariate analyses of disease-free survival in patients with colorectal cancer (Cox proportional hazards regression model)

	Univariate analysis				Multivariate analysis
Variables	HR	95% CI	P value		HR	95% CI	P value
Age
> 65 vs ≤ 65 years	0.81	0.59-1.12	0.198
Gender
Male vs Female	0.91	0.66-1.25	0.568
Tumor site
Rectum vs Colon	0.95	0.68-1.32	0.738
Tumor size
≥ 5 vs < 5 cm	1.54	1.11-2.12	0.009		1.33	0.95-1.86	0.096
Histological subtype
Adenocarcinoma vs others	0.88	0.47-1.61	0.670
Histological grage
Poor vs Well/Moderate	1.73	1.24-2.41	0.001		1.53	1.08-2.17	0.016
Depth of tumor invasion
T3+T4 vs T1+T2	2.56	1.70-3.87	<0.001		1.65	1.07-2.56	0.024
Lymph node metastasis
Presence vs Adsence	2.90	2.10-4.00	<0.001		1.78	1.24-2.57	0.002
Distant metastasis
Presence vs Adsence	6.79	4.77-9.67	<0.001		4.31	2.91-6.38	<0.001
Serum CEA level
≥ 10 vs < 10 ng/mL	1.50	1.07-2.10	0.019		1.30	0.91-1.86	0.144
GHRLOS expression
Decreased vs Non-decreased	2.20	1.57-3.09	<0.001		2.02	1.42-2.88	<0.001

HR, hazard ratio; CI, confidence interval; CEA, carcinoembryonic antigen.