Table 3.

Univariate and multivariate analyses for overall survival in patients with colorectal cancer (Cox proportional hazards regression model)

	Univariate analysis				Multivariate analysis
Variables	HR	95% CI	P value		HR	95% CI	P value
Age
> 65 vs ≤ 65 years	1.07	0.75-1.53	0.719
Gender
Male vs Female	0.98	0.70-1.38	0.904
Tumor site
Rectum vs Colon	1.21	0.83-1.77	0.312
Tumor size
≥ 5 vs < 5 cm	1.48	1.04-2.11	0.029		1.33	0.92-1.93	0.126
Histological subtype
Adenocarcinoma vs others	0.66	0.36-1.18	0.160
Histological grage
Poor vs Well/Moderate	1.64	1.15-2.35	0.006		1.56	1.07-2.27	0.020
Depth of tumor invasion
T3+T4 vs T1+T2	3.03	1.90-4.85	<0.001		1.77	1.08-2.91	0.023
Lymph node metastasis
Presence vs Adsence	3.63	2.55-5.19	<0.001		2.41	1.62-3.58	<0.001
Distant metastasis
Presence vs Adsence	5.81	3.96-8.54	<0.001		3.32	2.18-5.05	<0.001
Serum CEA level
≥ 10 vs < 10 ng/mL	1.51	1.05-2.17	0.025		1.32	0.91-1.93	0.147
GHRLOS expression
Decreased vs Non-decreased	2.16	1.50-3.11	<0.001		1.96	1.34-2.86	0.001

HR, hazard ratio; CI, confidence interval; CEA, carcinoembryonic antigen.