Table 3.

Risk factors (prevalence odds ratio, 95% CI) associated with patient death by univariate and multivariate analyses (Cox regression).

Risk factors, N (%)	Univariate analysis	Multivariate analysis	Multivariate analysis p value
Age > 62 years	1.1 (0.9 – 1.3)	not included
Gender Male	1.1 (0.9 – 1.4)	not included
Histology type of primary tumor
Adenocarcinoma	Comparator
Large cell carcinoma	1.3 (0.8 – 2.2)
Squamous cell carcinoma	1.3 (1.0 – 1.6)
Small cell lung cancer	2.3 (1.7 – 3.2)*	2.0 (1.5 – 2.8)	<0.001
Stages of cancer
Ia/Ib	comparator
IIa/IIb	1.6 (0.8 – 3.2)	2.5 (1.4 – 4.6)	0.002
IIIa/IIIb	2.7 (1.6 – 4.7)*	3.0 (1.7 – 5.4)	<0.001
IV	3.7 (2.2 – 6.2)*	-	ns
Extensive	3.9 (2.2 – 6.9)*	-	ns
Limited	2.7 (1.3 – 5.6)*	-	ns
No surgical treatment for lung cancer	comparator
Surgical treatment for lung cancer	0.4 (0.3 – 0.6)*	0.6 (0.4 – 0.9)	0.005
Time from PH to DX > 3 months	1.0 (0.8 – 1.2)	not included
Time from first app to DX > 2 months	1.2 (1.0 – 1.5)	not included
Time from DX to TTO < 1.5 months	1.8 (1.4 – 2.2)*	2.1 (1.6 – 2.6)	<0.001

^*p value <0.05 (univariate analysis by Cox regression).