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. 2017 Oct 20;60(22):9407–9412. doi: 10.1021/acs.jmedchem.7b01363

Scheme 1. Synthesis of Compounds 1a4a.

Scheme 1

Reagents and conditions: (a) hydrazine hydrate, triethylene glycol, 180 °C, 1.5 h; then KOH pellets, 180 °C, 2 h.