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. 2017 Oct 17;7(19):4699–4709. doi: 10.7150/thno.20654

Figure 1.

Figure 1

Concept for IgE cross-reactivity immune profiling (ICRIP) assay: characteristics of analytes used for the detection of IgE profiles. A) Each analyte has distinct glycan and peptide characteristics for the identification of anti-drug antibodies. Functional glycan content was determined by lectin binding assay (see Fig. S2). B) Specific binding patterns point to cross-reactive, thus common, epitopes, e.g., α-Gal as indicated by IgE binding to CTX, HSA-α-Gal and bovine TG. HSA: human serum albumin; bov (hu) TG: bovine (human) thyroglobulin; BSA: bovine serum albumin.