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. 2017 Oct 17;7(19):4699–4709. doi: 10.7150/thno.20654

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IgE binding patterns of A) IFX-treated patients, B) ADL-treated patients and C) non-treated control sera detected by ICRIP assay. Characteristics of assay components are described in Fig. 1. A positive signal was defined as being more intense than the background signal for the negative control serum NTC1 multiplied by a factor of 2. ADL: adalimumab; ADL PI: periodate-treated adalimumab (oxidation of glycans, thus interruption of antibody-glycan-binding); CTX: cetuximab; IFX: infliximab; HSA: human serum albumin; bov (hu) TG: bovine (human) thyroglobulin. Note that bov TG is used for commercial α-Gal ImmunoCAP® test (Thermo Fisher Scientific / Phadia, o215).