Figure 1.

Hepatic progenitor cells (oval cells) proliferated in small-for-size fatty grafts and exhibited dominant biliary differentiation. (A) Suppressed hepatocyte regeneration in small-for-size fatty grafts (Ki-67 staining, arrows) post-transplantation (n=6). (B) Statistical analysis of Ki-67 positive hepatocytes under microscopic examination. (C) Enhanced expression of Ov6 (hepatic progenitor cell marker, arrows) in the proliferative ductules of small-for-size fatty grafts (n=6). (D) Integrated intensity of Ov6 expression. (E) Increased proliferation of oval cells (Ov6 staining, arrows) in human small-for-size fatty graft. (F) Co-localization of Ov6 and E-cadherin (day 4, day 7) and development of defined lumina (arrowhead) on day 7 in the ductules of rat small-for-size fatty grafts. * p<0.05; ** p<0.01.