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. 2017 Nov 28;15:113. doi: 10.1186/s12915-017-0451-x

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© Ma et al. 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Decreased vascular density in Pparα ^-/- retinas. a Representative images of isolectin-labeled microvessels in retinal wholemount and single fields of superficial and deep vascular plexuses in central and peripheral retina of 40-week-old wild-type (WT) retinas. b Representative images of 40-week-old Pparα ^-/- retinas. c Decreased total vessel length in superficial and deep vascular plexuses of Pparα ^-/- retinas. d Decreased number of vascular junctions in superficial and deep vascular plexuses of Pparα ^-/- retinas. e Decreased number of meshes in deep vascular plexus of Pparα ^-/- retinas (adult retinas do not have meshing in the superficial plexus) (WT, n = 7; Pparα ^-/-, n = 8 retinas). *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; ****P ≤ 0.0001, Student’s t test