Table 10.

Summary of radius results extracted from CLSM by eight algorithms and compared to the reference radius measurements from SEM

Fluorescent Input	Radius ± stdev Estimate [um]		Number of points
Algorithm	ALL: Average ± stdev	Internal: Average ± s tdev	ALL	Internal
A1 (stats: single pixel)	2.2795 ± 0.6151	2.3075 ± 0.7189	32,608	22,128
A2 (stats: mixed pixel)	1.1190 ± 0.3128	1.1562 ± 0.3464	32,608	22,128
A4 (stats: noise model)	2.6851 ± 1.3196	2.7745 ± 1.5440	32,608	22,128
A5 (stats: MRF)	1.7532 ± 0.3353	1.7648 ± 0.3843	32,608	22,128
A6 (geom: σ= 1.0)	1.1139 ± 0.1960	1.0815 ± 0.2112	36,249	25,709
A7 (geom: σ= 1.5)	1.6251 ± 0.1065	1.6136 ± 0.1175	30,105	20,064
A8 (geom: thresh)	2.0404 ± 0.3567	2.0674 ± 0.4018	32,138	21,691
SEM Input	Average Radius: 1.1242 ± 0.075		Number of points: 104,341