Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov 29;15:50. doi: 10.1186/s12964-017-0205-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 7 — Sirt1 specifically repress TGFβ dependent transcriptional activity of DE-Luc reporter gene. a and b. Hep3B (a) and NIH3T3 (b) cells were transfected with the indicated plasmids. After 48 h cells were treated with TGFβ for 6 h and measured for luciferase activity. c Hep3B cells were additionally transfected with Sirt1 siRNA plasmids. After 48 h cells were treated with TGFβ for 6 h and measured for luciferase activity. “MIX”: Mixer transcription factor. “SCR”: Scramble sequence. Luciferase activity represents firefly luciferase activity normalized by Renilla activity. Asterisks denote significant differences according to ANOVA statistical analysis: *p < 0.05; ***p < 0.005 ***p < 0.001; ****p < 0.0001