Fig. 1.

For lipid encapsulations, droplet-to-microbubble vaporization requires rapid spreading of lipid at the gas/water interface to accommodate the area expansion. The elastic cohesion energy would resist both monolayer expansion and leaflet bending from the unfolding of surface-attached bilayers, and thus the cohesion energy may add to the overall energy barrier for vaporization. Reproduced with permission from [29]. Copyright 2015 American Chemical Society.