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. Author manuscript; available in PMC: 2017 Nov 29.
Published in final edited form as: Diabetes Metab Res Rev. 2011 Nov;27(8):746–754. doi: 10.1002/dmrr.1246

Figure 1.

Figure 1

Pancreatic insulin mRNA content and correlation with peripheral C-peptide levels and type 1 diabetes (T1D) duration. RNA was prepared from frozen sections and corresponding cDNA was used in a quantitative real-time polymerase chain reaction using primers against 18S ribosomal RNA for standardization. (A) A trend towards decreased insulin gene transcription is observed in T2D samples, while a statistically significant decrease is detected only in T1D versus non-diabetic (p = 0.0004; Mann–Whitney). (B) C-peptide measurement in blood at sampling plotted against insulin mRNA content. No significant correlations were observed, although C-peptide depletion in T1D subjects correlated well with low insulin mRNA levels. (C) Distribution of T1D cases according to duration and pancreatic insulin mRNA content. Significant insulin mRNA levels cluster in the earlier time range post-diagnosis. ND, non-diabetic; Ab+, islet autoantibody-positive at sampling; GD, gestational diabetes. Relative expression values across tested samples were calculated as outlined in Materials and methods section