Figure 3.

Glucose transporter 2 (GLUT2) is the dominant GLUT isoform in the NOD mouse and remains detectable under insulitic conditions. (A) A normal islet found in an 8-week-old female NOD mouse shows normal insulin production and strong GLUT2 expression. (B) A heavily inflamed islet from the same animal shows dramatically reduced insulin staining but persistent GLUT2 expression (white outline), except for the contact zone between infiltrate (red outline) and beta-cell mass. (C, D) In sharp contrast with rodents, GLUT2 could not be detected in any of the human islets examined