Table 5.
Multivariate logistic regression analysis of gout susceptibility with rare and common variants of ABCG2
| Variables | β | OR (95% CI) | p Value |
| Rare variant | 0.99 | 2.7 (1.4 to 5.2) | 3.0×10−3 |
| Q126X | 1.21 | 3.4 (2.0 to 5.6) | 3.1×10−6 |
| Q141K | 0.85 | 2.3 (1.9 to 2.9) | 2.7×10−16 |
Each variant was adjusted by the other two variants in this analysis.
Since the P268S variant of ABCG2 did not decrease urate transport activity, it was excluded from this analysis.
The A149P variant of ABCG2 was also excluded from this analysis due to its scores of SIFT and PolyPhen-2 as well as a previous report of functional analysis.18
ABCG2, ATP-binding cassette transporter subfamily G member 2; PolyPhen-2, Polymorphism Phenotyping v2; SIFT, Sorting Intolerant from Tolerant.