Figure 2.

Overexpression of WWC2 reduces the invasive ability of hepatocellular carcinoma (HCC) cells. (A) SMCC‐7721 cells transiently transfected with the WWC2 plasmid showed increased E‐cadherin expression and decreased N‐cadherin, vimentin and snail expression. (B) Knockdown of WWC2 decreased E‐cadherin expression and increased N‐cadherin, snail and vimentin expression in HepG2 cells. (C) Transient transfection of WWC2 into SMCC‐7721 cells decreased cell invasive ability (**P < 0.01). (D) Knockdown of WWC2 enhanced the invasive ability of HepG2 cells (**P < 0.01, t‐test).