Figure 3.

WWC2 is down‐regulated and correlates inversely with Yes‐associated protein (YAP) nuclear expression in human hepatocellular carcinoma (HCC). (A, B) Representative photomicrographs of WWC2 immunohistochemistry in HCC tissues and the matched adjacent non‐tumour tissues. In the adjacent liver tissues, WWC2 expression was generally positive (A) with cytoplasmic YAP expression (B). (C, D) In cases of HCC with high WWC2 protein expression (C), low nuclear YAP protein expression and strong cytoplasmic YAP protein expression were observed (D). (E, F) In cases of HCC with low WWC2 protein expression (E), low cytoplasmic YAP protein expression and strong nuclear YAP protein expression were observed (F).