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. 2017 Jun 29;21(12):3453–3466. doi: 10.1111/jcmm.13255

Figure 11.

Figure 11

Scheme of the possible sequence of the molecular mechanisms activated in the RPE by LED exposure. ROS: Reactive oxygen species, IRE: inositol requiring enzyme, XBP‐1: X‐box binding protein, PERK: protein endoplasmic reticulum kinase, CHOP: CCAAT enhancer‐binding protein homologous protein. NF‐kB: Nuclear factor kappa B, p62: sequestosome, LEI: leucocyte elastase inhibitor, PKC zeta: protein kinase C zeta, RIPk: receptor‐interacting protein kinase, BRB: blood–retinal barrier, HNE: hydroxynonenal.