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Schematic diagram summarizing how ocular inflammation of various etiologies or ocular surface dryness in DED, provoke variable increases (+) or decreases (−) of nerve impulse activity in polymodal- and mechano-nociceptors and in cold thermoreceptors of the high background, low threshold (HB-LT) and low background, high threshold (LB-HT) types. Together these changes evoke conscious sensations of different quality, as well as changes in tear flow and in spontaneous and reflex blinking.
