Table 1.
Corneal sensitivity and symptoms report in DED.
| Author(s)/Year | Subjects | Sensitivity (with ↑symptoms) | Aesthesiometer | Symptoms questionnaire |
|---|---|---|---|---|
| Xu et al. (1996) [447] | SS (n = 15) + DED (n = 44) | ↓ | COBO | not stated |
| Versura et al. (2007) [448] | SS (n = 66) + DED (n = 59) | ↓ | COBO | OSDI |
| Barboza et al. (2008) [449] | SS (n = 17) | ↓ | COBO | OSDI |
| Toker and Asfuroglu (2010) [450] | SS (n = 23) + DED (n = 14) | ↓cornea + conjunctiva | COBO | OSDI |
| Bourcier et al. (2005) [466] | SS (n = 14) + DED (n = 30) | ↓* | BGE | burning, itching, stinging |
| Benitez-del-Castillo et al. (2007) [460] | SS (n = 11) + DED (n = 10) | ↓* | BGE | not stated |
| De Paiva and Pflugfelder (2004) [457] | DED (n = 20) | ↑ | modified BGE | 11 items |
| Situ et al. (2008) [456] | DED (n = 43) | ↓* cornea + conjunctiva | modified BGE (20 °C) | OSDI, SeSOD |
| Tuisku et al. (2008) [371] | SS (n = 20) | ↑* | modified BGE | OSDI |
| Labbe et al. (2012) [452] | DED (n = 12) | ↓ | COBO | not measured |
| Kim et al. (2012) [451] | RA DE (n = 106) | ↓ | COBO | OSDI |
| Labbe et al. (2013) [372] | DED (n = 43) | ↓ | COBO | OSDI |
| Nepp and Wirth (2015) [453] | DED (n = 46) | ↓ | COBO | not measured |
| Rahman et al. (2015) [454] | MGD (n = 11) SS (n = 3) DED (n = 7) CC (n = 12) |
↓ (DED only) | COBO and Jet aesthesiometer (28 °C) | OSDI, VAS |
| Spierer et al. (2016) [458] | DED (n = 129) | ↑ | modified BGE (23–26 °C) | DEQ5, OSDI |
| Kaido et al. (2016) [462] | DED (n = 21) | No change in touch sensitivity ↑ pain sensitivity ↑ blink sensitivity |
COBO | 12 item questionnaire |
Key: SS, Sjögren’s Syndrome; DED, dry eye disease; DGE, Belmonte’s gas aesthesiometer; COBO, Cochet-Bonnet aesthesiometer; MGD, meibomian gland dysfunction; OSDI, ocular surface disease index; CC, conjunctivochalasis.