Table 1.
Distribution of clinical and pathologic variables by fibrosis stage. Results are in median (interquartile range) unless otherwise specified.
| N = 603 | Stage 0 N=14 |
Stage 1 N=287 |
Stage 2 N=166 |
Stage 3 N=68 |
Stage 4 N=68 |
P value for trend |
|---|---|---|---|---|---|---|
| Age, year | 47 (45–55) | 54 (49–58) | 54 (51–59) | 55 (51–60) | 56 (52–61) | <0.001 |
| Female, no (%) | 2 (14%) | 100 (35%) | 59 (36%) | 27 (40%) | 27 (40%) | 0.2 |
| Weight, pound | 168 (156–194) | 175 (160–200) | 179 (155–205) | 200 (156–217) | 199 (163–230) | 0.2 |
| BMI, kg/m2 | 28 (24–19) | 27 (24–31) | 27 (25–33) | 28 (24–34) | 28 (25–36) | 0.1 |
| Inflammation grade | 1 (1–1) | 1 (1–1) | 2 (2–2) | 3 (2–3) | 3 (2–3) | <0.001 |
| Iron grade | 6 (4–8) | 2 (1–3) | 1(1–2) | 1(1–4) | 1(1–6) | 0.1 |
| Iron in hepatocyte, no (%) | 5 (38%) | 143 (53%) | 74 (47%) | 31 (51%) | 31 (51%) | 0.1 |
| Steatosis, no (%) | 8 (62%) | 187 (67%) | 131 (79%) | 54 (81%) | 52 (80%) | 0.002 |
| HBV, no (%) | 0 | 8 (3%) | 7 (4%) | 6 (9%) | 1 (1%) | 0.4 |
| HIV, no (%) | 1 (7%) | 23 (8%) | 23 (14%) | 12 (18%) | 8 (12%) | 0.003 |
| CHF (congestive heart failure), no (%) | 1 (7%) | 9 (3%) | 6 (4%) | 0 | 0 | 0.1 |
| HTN (hypertension), no (%) | 1 (7%) | 33 (12%) | 27 (16%) | 18 (26%) | 15 (22%) | 0.02 |
| ESRD (end stage renal dis.), no (%) | 0 | 11 (4%) | 5 (3%) | 1 (1%) | 0 | 0.1 |
| DM (diabetes mellitus), no (%) | 6 (43%) | 53 (18%) | 44 (27%) | 15 (22%) | 14 (21%) | 0.1 |