A) An automated large-scale meta-analysis (NeuroSynth, Yarkoni et al., 2011) on the term “instructions” (FDR-corrected P < 0.01) shows significant activity in several regions discussed in this review, including the dACC, AI, and dlPFC. B) Example studies of instruction and suggestion effects across different experimental paradigms and functional domains, highlighting an important role for dlPFC in instruction-related changes in affective processing.