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The inhibition of AKT‐MMP‐2/9 by shRictor was consistent with that by the AKT inhibitor MK‐2206. (A) treatment with MK‐2206 disrupted the channels formation in 3D cultures (**P < 0.05,**P < 0.01). (B) MK‐2206 induced a decrease in the phosphorylation of AKT Ser473 and Thr308 and the expression of MMP‐2/9 (*P < 0.05). (C) the activity of MMP‐2 and MMP‐9 secreted by cells treated with different concentrations of MK‐2206 was detected by Zymography assay.
