• Introduction

• HCV life cycle

• HCV interaction with lipid and lipoprotein metabolism

– Lipids, lipoproteins and HCV structure

– Lipoprotein receptors and HCV entry into host cells

– Lipids and HCV replication, assembly and secretion

• PCSK9 and lipoprotein receptors

• The interaction between HCV and PCSK9

• Impact of anti‐PCSK9 mAbs on clinical outcome

• Conclusions