Figure 5.

Increased myeloperoxidase activity in CerS2 null mice with colitis. Mice were exposed to 2% (w/v) DSS in the drinking water for 7 days to induce colitis or normal plain water (control). (A) Ki‐67‐positive cells undergoing proliferation are stained DAB as a chromogen (200× magnification). Arrows indicated Ki‐67‐positive cells. (B) Myeloperoxidase (MPO) enzymatic activity was determined as an index of neutrophil infiltration into injured colon tissue. Results are means ± S.E.M. (n = 5). *P < 0.05, **P < 0.01. Images are typical of three independent experiments.