Figure 11.

Administrations of fumonisin B1 and myriocin in Cers2 null mice increase intestinal permeability. Mice were orally administered fumonisin B1 (1.5 mg/kg/day) or myriocin (0.5 mg/kg/day) for 3 days and then exposed to 2% (w/v) DSS in the drinking water for 7 days to induce colitis with coadministration with fumonisin B1 or myriocin. (A) Mice were orally administered 4 kDa FITC‐dextran (0.6 g/kg bodyweight) in 0.1 ml phosphate‐buffered saline, and fluorescence intensity in serum was then examined by spectrophotometry after 4 hrs. (B) Colon lengths of mice were measured. Results are expressed as means ± S.E.M. (n = 4). *P < 0.05, **P < 0.01. Con, control; Myri, myriocin; Fumo, fumonisin B1.