Figure 7.

Schematic summary of the anti‐fibrotic effect of miR‐30a in hepatic stellate cells. TGF‐β1 down‐regulates miR‐30a levels in HSCs and LX‐2‐exosomes, BDL or CCL4 down‐regulates miR‐30a levels in HSCs. MiR‐30a or si‐Beclin1 down‐regulates Beclin1 expression (Beclin1 mRNA is degraded into RNA fragments), decreases the number of autophagosomes, promotes lipid droplets (LDs) accumulation, stimulates extracellular matrix (ECM) degradation, suppresses collagen production and results in the amelioration of liver fibrosis.