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. 2017 Jul 26;21(12):3670–3678. doi: 10.1111/jcmm.13277

Figure 2.

Figure 2

Antiadrenergic effect of obestatin in isolated rat papillary muscle. The positive inotropic effect of ISO (100 nM) is compared with that exerted by ISO in the presence of 50 nM obestatin (OBE). L‐NNA (1 mM), WN (100 nM), ODQ (10 μM) and (D‐Lys3)‐GHRP‐6 (1 μM) were used to block NO synthesis, PI3K or sGC activity, and the ghrelin receptor GHSR‐1a, respectively. Triton X‐100 (0.5%) was used to remove endocardial endothelium. Values are expressed as % of the contraction force induced by ISO alone. **P < 0.01 ISO + OBE or ISO + OBE + GHRP‐6 versus ISO alone; ## P < 0.01 ISO + OBE versus ISO + OBE + inhibitors and Triton.