Table 1.
Plasma Pharmacokinetic Parameters for Chol-hsiRNA and PC-DHA-hsiRNA Conjugates After Intravenous Administration
| Parameter | Unit | PC-DHA-hsiRNA | Chol-hsiRNA |
|---|---|---|---|
| k | 1/min | 0.0008 | 0.0013 |
| t1/2β | min | 849.8 | 515.8 |
| t1/2α | min | 17.8 | 33.2 |
| Cmax | μg/mL | 572.3 | 753.4 |
| AUC0–48h | μg/(mL·min) | 15249.2 | 54532.5 |
| AUC0–inf | μg/(mL·min) | 15381.0 | 54807.5 |
| MRT0–inf | min | 107.4 | 156.9 |
| Vz | mL | 42.3 | 6.8 |
| Cl | mL/min | 0.0345 | 0.0091 |
AUC, area under the curve; Chol-hsiRNA, cholesterol-hsiRNA; MRT, mean residence time; PC-DHA-hsiRNA, phosphocholine-docosahexaenoic acid-hsiRNA.