Table 2.

Plasma Pharmacokinetic Parameters for Chol-hsiRNA and PC-DHA-hsiRNA Conjugates After SC Administration

Parameter	Unit	PC-DHA-hsiRNA	Chol-hsiRNA
ka	1/min	0.0431	0.0116
t1/2 absorption	min	16.1	59.8
k	1/min	0.0006	0.0016
t1/2β	min	1075.4	428.1
Tmax	min	30–60	180–240
Cmax	μg/mL	50.5	14.0
AUC0–48h	μg/(mL·min)	8322.5	11517.8
AUC0–inf	μg/(mL·min)	8653.2	11654.0
MRT0–inf	min	377.9	549.6
Vz/F	mL	95.2	26.5
Cl/F	mL/min	0.0614	0.0429