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. 2017 Dec 1;27(6):345–353. doi: 10.1089/nat.2017.0683

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© Shashi Gupta et al. 2017; Published by Mary Ann Liebert, Inc.

This article is available under the Creative Commons License CC-BY-NC (http://creativecommons.org/licenses/by-nc/4.0). This license permits non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. Permission only needs to be obtained for commercial use and can be done via RightsLink.

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FIG. 3. — Effect of number of side chains. (A) Individual sequences (5′→3′) that make up Series C, D, E, and F designed for the determination of the effect of the number of side chains on rat plasma PK. Standard single-letter designations (A, C, G, and U) are used for the unmodified dehydroxy nucleobases, whereas positions designated Z and P (highlighted in red text) are as described in Fig. 1. The positions containing 2′-OMe ribose are shaded gray. All sequences contain a 3′-idT cap, are fully modified with 2′-OMe ribose except for positions containing a C3 spacer (L) in place of a nucleotide (positions 13 and 14 of Series D and F) and have a 40 kDa PEG attached to the 5′-terminus (not shown). The number of side chains and plasma clearance is shown next to each sequence. (B) Linear regression analyses of plasma clearance (CL) versus the number of side chains in Series C and D. (C) Linear regression analyses of plasma clearance (CL) versus the number of side chains in Series E and F.