Table 1.

Pharmacokinetic Properties of Shorter Active Aptamers with Side Chains

Modified aptamer	Aptamer length	Number of side chains	Number of 2′-OMe	t1/2 (h)	Clearance [mL/(h*kg)]
SL1028	17	5	2	3.9	6.9
SL1068	21	5	11	9.6	4.4

2′-OMe, 2′-methoxy.