Table 1.
Modified aptamer | Aptamer length | Number of side chains | Number of 2′-OMe | t1/2 (h) | Clearance [mL/(h*kg)] |
---|---|---|---|---|---|
SL1028 | 17 | 5 | 2 | 3.9 | 6.9 |
SL1068 | 21 | 5 | 11 | 9.6 | 4.4 |
2′-OMe, 2′-methoxy.
Modified aptamer | Aptamer length | Number of side chains | Number of 2′-OMe | t1/2 (h) | Clearance [mL/(h*kg)] |
---|---|---|---|---|---|
SL1028 | 17 | 5 | 2 | 3.9 | 6.9 |
SL1068 | 21 | 5 | 11 | 9.6 | 4.4 |
2′-OMe, 2′-methoxy.