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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Expert Opin Ther Targets. 2017 May 29;21(7):657–669. doi: 10.1080/14728222.2017.1323880

Figure 3.

Figure 3

Targeting MUC4 regulatory elements in PDAC cells. In the tumor microenvironment, MUC4 regulation is under the control of different cytokines, ligands and receptors. Depending upon the cytokine milieu, various downstream signaling pathways are activated leading to MUC4 overexpression. Inhibiting (┬) these regulatory switches (receptor ligand interactions, intracellular signaling pathways, transcription factors, post-translational modifications) with natural products or pharmacological agents may abrogate MUC4-mediated processes and can be of therapeutic significance against PDAC.