Guggulsterone (4,17(20)-pregnadiene-3,16-dione |
Downregulation |
JAK/STAT and FAK/Src/MM9 pathway inhibition |
Reduced proliferation and invasion |
Macha et al. 2013 |
Thymoquinone (2-isopropyl-5-methylbenzo-1,4-quinone) |
Downregulation |
Synergistic to gemcitabine and oxaliplatin |
Enhanced apoptosis, reduced proliferation and metastasis |
Torres et al. 2010; Banerjee et al. 2009; Wu et al. 2011
|
Graviola extract
(Annona muricata)
|
Downregulation |
Not known |
Antiproliferative and antimetastatic |
Torres et al. 2012 |
miR-150 |
Direct-targeting MUC4 leading to inhibition |
Reduces pEGFR and HER-2 downstream signaling |
Antiproliferative and antimetastatic |
Yang et al. 2014; Srivastava et al. 2011; Arora et al. 2014
|
miR-200c |
Downregulate MUC4 along with MUC16 |
Not known |
Reduced cell proliferation |
Radhakrishnan et al. 2013 |
miR-219-1-3p |
Downregulation |
Cyclin D1/ERK/AKT downregulation |
Decrease of cyclin D1 expression and decreased Erk and Akt ativation |
Lahdaoui et al. 2015 |
Canertinib |
Downregulation |
Through EGFR and HER2 |
Antiproliferative and antimetastatic |
Seshacharyulu et al. 2015 |
Afatinib |
Downregulation |
|
|
|