Fig. 3. Atomoxetine produces no effect on the heart rate in anesthetized DBA/1 mice.
A, representative ECG traces in anesthetized DBA/1 mice treated with vehicle (saline 10 ml/kg, IP) or atomoxetine (15 mg/kg, IP) in room air. B, comparison of the normalized mean heart rate between vehicle and atomoxetine in room air and in room air plus 7% CO2 at the period of 120–130 min (mean value of 10-min recordings) after injection of vehicle/atomoxetine, at which atomoxetine at this dosage is known to reduce S-IRA (Zhang et al., 2017).