Table 3.
MDD gene risk score association with secondary phenotypes. Gene risk score explained in Supplementary Table 6. MDD age-at-onset associations were conducted in subjects with MDD. All other trait associations were conducted in cases and controls and adjusted for case/control status from the general 23andMe research community.
| Phenotype | N | effect (SE) | pvalue | FDR |
|---|---|---|---|---|
| Early-onset | 94891 | 0.283 (0.095) | 2.90E-03 | 3.20E-03 |
| Age-of-onset | 94891 | −1.49 (0.372) | 6.10E-05 | 8.40E-05 |
| Anxiety | 250528 | 0.323 (0.061) | 1.00E-07 | 2.50E-07 |
| Panic attacks | 247167 | 0.319 (0.072) | 9.80E-06 | 1.50E-05 |
| Insomnia | 248576 | 0.272 (0.051) | 1.10E-07 | 2.50E-07 |
| Taking an SSRI | 52698 | 0.448 (0.162) | 5.50E-03 | 5.50E-03 |
| Medication for mental health | 349287 | 0.421 (0.057) | 1.40E-13 | 1.50E-12 |
| Prescription sleep aid | 350119 | 0.184 (0.05) | 2.70E-04 | 3.20E-04 |
| Prescription pain medication | 346989 | 0.236 (0.041) | 5.60E-09 | 3.10E-08 |
| Overweight (BMI>27) | 401552 | 0.212 (0.038) | 3.00E-08 | 1.10E-07 |
| Obesity (BMI>30) | 401552 | 0.216 (0.045) | 1.50E-06 | 2.70E-06 |