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. 2017 Sep 28;8(55):93360–93372. doi: 10.18632/oncotarget.21382

Figure 8. miR-9 inducing small molecule attenuated neointima formation after balloon injury.

Figure 8

A. Representative images of H&E staining showed neointima formation in a BI animal model sacrificed at 3 weeks after BI. In the SQ treated group, the animals received 1.64mg/kg of SQ via an i.v. injection. M: media, A: adventitia, I: intima. B. The expression of miR-9 in the corresponding group (n = 5 per group). *p < 0.05 compared to the BI without SQ treatment. C. Immunohistochemical staining of PDGFRβ. SM α-actin stained VSMCs and DAPI stained nuclei. L: lumen. D. Schematics showing proposed mechanism of SQ-induced miR-9 up-regulation and subsequent inhibition of VSMC proliferation.