Table 2. Associations of SNPs with childhood obesity.
| SNP | Nearest gene | a/A* | MAF† | P (HWE)‡ | Normal vs Obesity | Normal vs Overweight & Obesity | BMI (kg/m2) | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR(95% CI) | P § | OR (95% CI) | P § | β (95% CI) | P § | ||||||
| rs1558902 | FTO | intron | T/A | 0.10 | 0.02 | 1.421 (1.198-1.686) | 5.6E-5 | 1.405 (1.204-1.639) | 1.58E-5 | 0.831 (0.509-1.154) | 4.6E-7 |
| rs2331841 | MC4R | near | A/G | 0.22 | 0.82 | 1.267 (1.111-1.445) | 4.4E-4 | 1.212 (1.079-1.363) | 0.001 | 0.486 (0.238-0.735) | 1.3E-4 |
| rs16858082 | GNPDA2 | near | C/T | 0.34 | 0.56 | 1.239 (1.102-1.393) | 3.4E-4 | 1.220 (1.100-1.353) | 1.68E-4 | 0.384 (0.164-0.604) | 0.001 |
| rs261967 | PCSK1 | intron | A/C | 0.41 | 0.24 | 1.212 (1.081-1.359) | 0.001 | 1.164 (1.052-1.288) | 0.003 | 0.311 (0.095-0.528) | 0.005 |
| rs516636 | SEC16B | near | C/A | 0.20 | 0.38 | 1.221 (1.064-1.401) | 0.004 | 1.224 (1.082-1.384) | 0.001 | 0.371 (0.110-0.631) | 0.005 |
| rs4776970 | MAP2K5 | intron | T/A | 0.22 | 0.01 | 1.211 (1.063-1.379) | 0.004 | 1.207 (1.076-1.355) | 0.001 | 0.347 (0.101-0.594) | 0.006 |
| rs2535633 | ITIH4 | intron | C/G | 0.41 | 0.52 | 1.157 (1.033-1.295) | 0.012 | 1.122 (1.015-1.241) | 0.024 | 0.221 (0.006-0.436) | 0.044 |
| rs2030323 | BDNF | intron | T/G | 0.47 | 0.95 | 1.133 (1.011-1.270) | 0.031 | 1.117 (1.011-1.235) | 0.030 | 0.216 (0.004-0.428) | 0.046 |
| rs6545814 | ADCY3/RBJ | intron | A/G | 0.41 | 0.89 | 1.107 (0.989-1.240) | 0.078 | 1.073 (0.969-1.187) | 0.175 | 0.219 (0.002-0.435) | 0.047 |
| rs652722 | PAX6 | intron | T/C | 0.34 | 0.75 | 0.937 (0.832-1.056) | 0.287 | 0.936 (0.843-1.040) | 0.219 | -0.118 (-0.343-0.107) | 0.303 |
| rs12597579 | GP2 | intron | T/C | 0.28 | 0.52 | 1.069 (0.942-1.213) | 0.303 | 1.049 (0.939-1.173) | 0.395 | 0.139 (-0.099-0.378) | 0.252 |
| rs2237892 | KCNQ1 | intron | T/C | 0.31 | 0.07 | 0.983 (0.872-1.109) | 0.783 | 0.982 (0.883-1.092) | 0.737 | 0.052 (-0.176-0.279) | 0.655 |
| 12 loci | GPSall | / | / | / | / | 1.150 (1.108-1.194) | 2.4E-13 | 1.128 (1.091-1.166) | 9.1E-13 | 0.261 (0.193-0.330) | 9.4E-14 |
*a: non-effect; A: effect; † minor allele frequency; ‡P value for Hardy-Weinberg equilibrium test; OR/β (95% CI) and §P value for logistic/linear regression in the additive model were adjusted for gender, age, Tanner stage and residence.
Abbreviation: MC4R, melanocortin 4 receptor; FTO, fat mass and obesity associated; GNPDA2, glucosamine-6-phosphate deaminase 2; PCSK1, proprotein convertase subtilisin/kexin type 1; SEC16B, SEC16 homolog B, endoplasmic reticulum export factor; MAP2K5, mitogen-activated protein kinase 5; ITIH4, inter-alpha-trypsin inhibitor heavy chain family, member 4; BDNF, brain-derived neurotrophic factor; ADCY3/RBJ, adenylate cyclase 3; PAX6, paired box 6; GP2, glycoprotein 2; KCNQ1, potassium channel, voltage gated KQT-like subfamily Q, member 1 and GPSall, sum gene score of all 12 loci.
Note: Values in bold are significant at P < 0.05