Table 3. Associations of the selected SNPs and GPS with five adipokines.

Gene	SNP		Leptin (ng/ml)#	Adiponectin (ug/ml)#	Resistin (ng/ml)#	FGF21 (pg/ml)#	RBP4 (ug/ml)#
FTO	rs1558902	β	0.149	-0.027	0.019	0.022	0.004
		P	0.002	0.202	0.342	0.664	0.760
MC4R	rs2331841	β	0.110	-0.038	0.011	0.012	0.009
		P	0.003	0.020	0.454	0.764	0.340
GNPDA2	rs16858082	β	0.089	-0.004	-0.005	-0.006	0.003
		P	0.007	0.800	0.721	0.815	0.736
SEC16B	rs516636	β	0.067	-0.025	0.013	-0.059	0.015
		P	0.088	0.153	0.402	0.150	0.157
PCSK1	rs261967	β	0.087	0.030	0.012	-0.005	0.007
		P	0.007	0.038	0.350	0.882	0.423
MAP2K5	rs4776970	β	0.114	-0.020	0.006	-0.012	0.014
		P	0.002	0.212	0.674	0.749	0.138
ITIH4	rs2535633	β	0.050	-0.005	-0.022	-0.006	0.011
		P	0.118	0.719	0.094	0.868	0.185
BDNF	rs2030323	β	0.071	-0.030	0.005	-0.035	-0.007
		P	0.027	0.032	0.683	0.291	0.414
ADCY3/RBJ	rs6545814	β	0.050	-0.016	-0.013	-0.024	3.79E-4
		P	0.123	0.277	0.323	0.469	0.966
GPSall	all 12 loci	β	0.062	-0.010	0.001	-0.02	0.004
		P	9.7E-10	0.022	0.807	0.064	0.128
		Explained variation	1.0%	0.1%	< 0.01%	< 0.01%	< 0.01%

β means linear regression coefficients adjusted for gender, age, Tanner stage and residence.

Abbreviation: FGF21, fibroblast growth factor 21; RBP4, retinol binding protein 4; FTO, fat mass and obesity associated; MC4R, melanocortin 4 receptor; GNPDA2, glucosamine-6-phosphate deaminase 2; SEC16B, SEC16 homolog B, endoplasmic reticulum export factor; PCSK1, proprotein convertase subtilisin/kexin type 1; MAP2K5, mitogen-activated protein kinase 5; ITIH4, inter-alpha-trypsin inhibitor heavy chain family, member 4; BDNF, brain-derived neurotrophic factor ; ADCY3/RBJ, adenylate cyclase 3 and GPS_all, sum gene score of all 12 loci.

^# Skewed distributions were natural logarithmically (ln) transformed.

Note: Values in bold are significant at P < 0.004 after Bonferroni correction.