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. 2017 Aug 24;8(55):93593–93607. doi: 10.18632/oncotarget.20547

Table 5. Associations of the 12 SNPs and GPSs with obesity-related and other cardio-metabolic traits.

Gene SNP WC (cm) Percent body fat UAC (cm) SBP (mmHg) DBP (mmHg) TC (mmol/L) TG (mmol/L)# LDL-C (mmol/L) HDL-C (mmol/L) FBG (mmol/L) Insulin (mU/L)# HOMA-IR#
FTO rs1558902 β 1.887 1.150 0.857 1.491 0.964 -0.020 0.007 -0.007 -0.011 -0.011 0.058 0.057
P 6.3E-6 1.5E-4 2.5E-8 0.001 0.005 0.496 0.683 0.807 0.322 0.599 0.031 0.044
MC4R rs2331841 β 1.183 0.847 0.482 0.588 0.300 -0.007 0.026 -0.001 -0.012 0.046 0.064 0.072
P 2.3E-4 2.8E-4 4.7E-5 0.096 0.260 0.757 0.045 0.946 0.184 0.004 0.002 0.001
GNPDA2 rs16858082 β 0.974 0.665 0.265 0.852 0.421 -0.048 0.005 -0.030 -0.021 0.017 0.056 0.059
P 0.001 0.001 0.011 0.006 0.074 0.017 0.643 0.109 0.006 0.231 0.002 0.002
SEC16B rs516636 β 0.972 0.493 0.279 0.575 0.148 0.003 0.015 0.008 -0.012 0.011 0.039 0.041
P 0.004 0.044 0.025 0.121 0.595 0.884 0.268 0.715 0.180 0.518 0.073 0.068
PCSK1 rs261967 β 0.790 0.339 0.287 0.406 0.508 -0.042 0.009 -0.024 -0.015 -0.014 0.042 0.041
P 0.005 0.091 0.005 0.186 0.028 0.031 0.414 0.189 0.049 0.292 0.020 0.028
MAP2K5 rs4776970 β 0.982 0.704 0.338 0.709 0.424 4.5E-4 0.030 0.001 -0.023 -0.015 0.035 0.032
P 0.002 0.002 0.004 0.043 0.107 0.984 0.017 0.978 0.010 0.321 0.086 0.140
ITIH4 rs2535633 β 0.586 0.430 0.165 0.266 0.109 0.033 0.019 0.037 -0.006 -0.001 0.036 0.035
P 0.035 0.033 0.107 0.384 0.634 0.092 0.084 0.032 0.396 0.939 0.045 0.060
BDNF rs2030323 β 0.386 0.343 0.191 -0.284 -0.262 0.016 0.006 0.018 -0.004 -0.004 0.029 0.027
P 0.163 0.087 0.062 0.351 0.254 0.418 0.615 0.326 0.600 0.763 0,105 0.141
ADCY3
RBJ 		rs6545814 β 0.599 0.367 0.177 0.385 0.395 -0.007 0.002 0.009 -0.008 -0.019 0.025 0.023
P 0.032 0.070 0.086 0.211 0.088 0.728 0.865 0.625 0.290 0.160 0.157 0.226
KCNQ1 rs2237892 β 0.271 0.135 0.048 -0.231 0.038 -0.041 0.020 -0.027 -0.028 0.016 0.008 0.011
P 0.356 0.527 0.659 0.475 0.876 0.046 0.094 0.159 0.001 0.257 0.687 0.587
PAX6 rs652722 β -0.143 -0.044 -0.132 0.127 0.053 -0.016 -0.014 -0.010 -0.004 -0.017 -0.010 -0.013
P 0.622 0.834 0.218 0.690 0.825 0.439 0.223 0.584 0.647 0.225 0.601 0.511
GP2 rs12597579 β 0.474 0.164 0.119 0.168 0.183 0.016 0.010 0.009 -3.5E-4 0.002 -0.004 -0.003
P 0.124 0.462 0.294 0.619 0.472 0.471 0.396 0.662 0.967 0.921 0.857 0.869
GPSall all 12 loci β 0.683 0.418 0.226 0.397 0.26 -0.009 0.011 1.2E-4 -0.013 0.001 0.033 0.033
P 1.4E-14 6.1E-11 3.5E-12 4.7E-5 4.1E-4 0.178 0.002 0.983 2.7E-7 0.735 7.3E-9 1.7E-8
EV 1.3% 1.2% 1.0% 0.4% 0.3% < 0.01% 0.3% < 0.01% 0.8% < 0.01% 0.9% 0.8%
GPSleptin six leptin-related loci β 0.972 0.608 0.352 0.523 0.315 -0.017 0.013 -0.007 -0.015 0.004 0.046 0.047
P 2.3E-13 3.4E-11 4.1E-14 1.8E-4 0.003 0.050 0.008 0.392 2.3E-5 0.529 1.2E-8 2.9E-8
EV 1.3% 1.2% 1.2% 0.4% 0.3% < 0.01% 0.2% < 0.01% 0.6% < 0.01% 1.0% 1.0%

β means linear regression coefficients adjusted for gender, age, Tanner stage and residence.

Abbreviation: BMI, body mass index; WC, waist circumference; UAC, upper arm circumference; SBP, systolic blood pressure; DBP, diastolic blood pressure; TC, total cholesterol; TG, triglycerides; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; FBG, fasting blood glucose; HOMA-IR, homeostasis model assessment for insulin resistance; EV, explained variation; FTO, fat mass and obesity associated; MC4R, melanocortin 4 receptor; GNPDA2, glucosamine-6-phosphate deaminase 2; SEC16B, SEC16 homolog B, endoplasmic reticulum export factor; PCSK1, proprotein convertase subtilisin/kexin type 1; MAP2K5, mitogen-activated protein kinase 5; ITIH4, inter-alpha-trypsin inhibitor heavy chain family, member 4; BDNF, brain-derived neurotrophic factor; ADCY3/RBJ, adenylate cyclase 3; KCNQ1, potassium channel, voltage gated KQT-like subfamily Q, member 1; PAX6, paired box 6; GP2, glycoprotein 2; GPSall, sum gene score of all 12 loci and GPSleptin, sum gene score of six leptin-related loci.

# Skewed distributions were natural logarithmically (ln) transformed.

Note: Values in bold are significant at P < 0.004 after Bonferroni correction.