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. 2017 Aug 24;8(55):93593–93607. doi: 10.18632/oncotarget.20547

Table 6. Associations of the 12 SNPs and GPSs with obesity-related and other cardio-metabolic traits after adjusting for BMI.

Gene SNP WC (cm) Percent body fat UAC (cm) SBP (mmHg) DBP (mmHg) TC (mmol/L) TG (mmol/L)# LDL-C (mmol/L) HDL-C (mmol/L) FBG (mmol/L) Insulin (mU/L)# HOMA-IR#
FTO rs1558902 β -0.084 -0.053 0.138 0.301 0.257 -0.023 -0.022 -0.024 0.012 -0.022 -0.019 -0.022
P 0.561 0.746 0.017 0.451 0.419 0.444 0.165 0.380 0.241 0.273 0.407 0.359
MC4R rs2331841 β 0.052 0.155 0.061 -0.096 -0.121 -0.009 0.010 -0.012 -0.002 0.040 0.021 0.028
P 0.640 0.220 0.171 0.754 0.620 0.684 0.423 0.572 0.852 0.012 0.222 0.123
GNPDA2 rs16858082 β 0.036 0.038 -0.066 0.306 0.103 -0.048 -0.008 -0.037 -0.010 0.012 0.023 0.025
P 0.712 0.735 0.091 0.258 0.634 0.016 0.434 0.046 0.144 0.396 0.128 0.115
SEC16B rs516636 β 0.081 -0.059 -0.043 0.067 -0.154 0.002 0.003 0.001 -0.002 0.005 0.007 0.009
P 0.490 0.656 0.360 0.833 0.547 0.932 0.833 0.981 0.789 0.749 0.696 0.645
PCSK1 rs261967 β 0.049 -0.135 0.018 -0.040 0.245 -0.044 -0.001 -0.031 -0.006 -0.018 0.013 0.012
P 0.609 0.221 0.635 0.879 0.247 0.026 0.896 0.089 0.365 0.177 0.369 0.452
MAP2K5 rs4776970 β 0.155 0.175 0.057 0.247 0.153 -4.0E-4 0.019 -0.006 -0.013 -0.020 0.005 0.001
P 0.158 0.162 0.196 0.415 0.525 0.986 0.107 0.765 0.102 0.194 0.759 0.956
ITIH4 rs2535633 β 0.028 0.098 -0.026 -0.058 -0.083 0.032 0.012 0.034 -1.7E-4 -0.004 0.015 0.014
P 0.771 0.373 0.496 0.826 0.693 0.101 0.267 0.059 0.980 0.777 0.306 0.371
BDNF rs2030323 β -0.105 -0.04 0.007 -0.587 -0.434 0.016 -0.003 0.013 0.003 -0.008 0.009 0.007
P 0.272 0.713 0.850 0.026 0.039 0.417 0.800 0.455 0.662 0.578 0.527 0.641
ADCY3/RBJ rs6545814 β 0.121 0.07 -0.012 0.060 0.202 -0.007 -0.006 0.004 -0.002 -0.022 0.006 0.002
P 0.211 0.528 0.762 0.822 0.341 0.707 0.568 0.815 0.811 0.109 0.704 0.876
KCNQ1 rs2237892 β 0.114 0.028 0.003 -0.295 0.002 -0.042 0.018 -0.028 -0.026 0.015 0.003 0.006
P 0.262 0.812 0.937 0.291 0.994 0.044 0.102 0.142 3.7E-4 0.291 0.852 0.735
PAX6 rs652722 β 0.106 0.077 -0.028 0.283 0.155 -0.015 -0.010 -0.008 -0.007 -0.016 0.001 -0.002
P 0.290 0.504 0.481 0.304 0.481 0.452 0.365 0.680 0.323 0.271 0.948 0.916
GP2 rs12597579 β 0.119 -0.108 -0.003 -0.045 0.047 0.015 0.005 0.005 0.004 -2.8E-4 -0.017 -0.017
P 0.264 0.375 0.948 0.878 0.839 0.492 0.645 0.794 0.619 0.985 0.315 0.330
GPSall all 12 loci β 0.057 0.023 0.001 0.033 0.04 -0.01 0.002 -0.005 -0.005 -0.002 0.009 0.009
P 0.065 0.512 0.939 0.702 0.562 0.139 0.540 0.389 0.019 0.634 0.050 0.072
GPSleptin six leptin- related loci β 0.017 0.018 0.022 -0.024 -0.006 -0.019 1.7E-4 -0.015 -0.004 -0.001 0.012 0.012
P 0.696 0.723 0.204 0.843 0.952 0.036 0.972 0.064 0.242 0.826 0.081 0.099

β means linear regression coefficients adjusted for gender, age, Tanner stage, residence and BMI.

Abbreviation: BMI, body mass index; WC, waist circumference; UAC, upper arm circumference; SBP, systolic blood pressure; DBP, diastolic blood pressure; TC, total cholesterol; TG, triglycerides; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; FBG, fasting blood glucose; HOMA-IR, homeostasis model assessment for insulin resistance; FTO, fat mass and obesity associated; MC4R, melanocortin 4 receptor; GNPDA2, glucosamine-6-phosphate deaminase 2; SEC16B, SEC16 homolog B, endoplasmic reticulum export factor; PCSK1, proprotein convertase subtilisin/kexin type 1; MAP2K5, mitogen-activated protein kinase 5; ITIH4, inter-alpha-trypsin inhibitor heavy chain family, member 4; BDNF, brain-derived neurotrophic factor; ADCY3/RBJ, adenylate cyclase 3; KCNQ1, potassium channel, voltage gated KQT-like subfamily Q, member 1; PAX6, paired box 6; GP2, glycoprotein 2; GPSall, sum gene score of all 12 loci and GPSleptin, sum gene score of six leptin-related loci.

# Skewed distributions were natural logarithmically (ln) transformed.

Note: Values in bold are significant at P < 0.004 after Bonferroni correction.