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. 2017 Oct 4;8(55):93712–93728. doi: 10.18632/oncotarget.21477

Figure 6. Both CMP and cordycepin inhibited the production of IL-17A.

Figure 6

(A) Levels of IL-17A in the culture supernatants of lymph nodes and splenocytes and in the serum. Data are presented as mean ± SEM and statistical analysis is performed with one-way ANOVA following Tukey’s test. (B) Cordycepin significantly inhibited IL-17A expression and IL-17A-expressing CD3+ CD4+ splenocytes after 3 days of ex vivo differentiation. The content of Th17 promoting agents is described in the Materials and Methods. (C) Cordycepin did not cause significant cell death in terms of LDH release and annexin v signaling. Data are presented as mean ± SD and statistical analysis is effectuated with one-way ANOVA following the Tukey’s test. (D) Cordycepin suppressed IL-17A production in tumor-draining lymph node cells. Representative results from three independent experiments are shown. Data are presented as mean ± SD and statistical analysis is conducted with one-way ANOVA following Tukey’s test. CLN: cervical lymph nodes; LDH: lactate dehydrogenase.