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. 2017 Oct 6;8(55):94069–94079. doi: 10.18632/oncotarget.21578

Figure 1. IL-10-producing Breg cells exhibit lower miR-21 expression than non-Breg cells.

Figure 1

(A) CD4+ T cells and CD19+ B cells were purified by MACS from the spleens of EAE mice at disease onset (day 14), and miR-21 expression was analyzed by qRT-PCR using U6 snRNA as an endogenous control. (B, C) CD5+CD1dhi and CD5-CD1d- B cells (B) and TIM-1+ and TIM-1- B cells (C) were sort-purified from the spleens of EAE mice at the onset stage (day 14), and miR-21 expression was analyzed by qRT-PCR using U6 snRNA as an endogenous control. The data are representative of 3 independent experiments. The bars and error bars represent the mean ± SEM. **P < 0.01.

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