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. 2017 Oct 6;8(55):94129–94141. doi: 10.18632/oncotarget.21588

Figure 6. Crosstalk of apoptosis and necroptosis pathways limits initiation of autophagy in human lung cancer cells.

Figure 6

Immunoblotting at 48 h post-transfection using monoclonal antibodies against autophagy-related proteins (LC3-I, LC3-II, Beclin-1, and Bcl-2) in A549 cells, with and without a P53 inhibitor (A) and in H1299 cells, with and without a necrosis inhibitor (B). ß-actin was used as a loading control. (C and D) Quantification of the results in A and B, respectively. Error bars represent the SEM of 3 independent experiments. All data were analyzed using a paired or unpaired Student’s t-test, as appropriate. *p < 0.01 indicates statistical significance.