Table 3. Composition and observed responses from runs.

Mixture number	Formulation composition			Response measured
	X1	X2	X3	Y1	Y2	Y3	Y4
(A) Optimized S-SuSMEDDS granules
	Florite® PS-10 (%)	Vivapur® 105 (%)	N.A.a	CSR (g/mL)	D15 (%)	N.A.	N.A.
1	0	100	-	1.8	64.3	-	-
2	25	75	-	1.45	59.3	-	-
3	50	50	-	1.1	55.5	-	-
4	75	25	-	0.8	52.7	-	-
5	100	0	-	1.4	46.6	-	-
6	0	100	-	1.8	62.8	-	-
7	50	50	-	1.15	54.4	-	-
8	100	0	-	0.42	45.7	-	-
(B) Optimized S-SuSMEDDS tablets
	Compression force (%)	Conc. of super-disintegrant (%)	Type of super-disintegrant	Hardness (N)	Disint (%)	DE (%)	Total mass (mg)
1	500	2	CS	77	23.8	3.4	466.1
2	1250	2	CS	93	23.0	3.3	465.5
3	2000	2	CS	66	23.0	3.1	466.2
4	500	5	CS	76	89.2	27.3	478.2
5	1250	5	CS	72	84.9	28.8	480.5
6	2000	5	CS	73	87.2	28.8	476.6
7	500	8	CS	75	100.0	38.6	489.6
8	1250	8	CS	77	100.0	39.5	489.7
9	2000	8	CS	71	100.0	38.9	493.1
10	500	2	KC	74	16.9	3.8	464.3
11	1250	2	KC	81	18.3	4.3	461.8
12	2000	2	KC	69	19.1	5.3	466.5
13	500	5	KC	80	63.8	32.2	476.3
14	1250	5	KC	88	59.8	33.8	479.3
15	2000	5	KC	82	62.6	31.7	480.5
16	500	8	KC	74	89.5	42.8	493.8
17	1250	8	KC	84	90.1	41.3	490.2
18	2000	8	KC	80	92.0	40.6	489.9
19	500	2	SSG	68	23.8	4.5	461.3
20	1250	2	SSG	86	27.3	4.8	463.7
21	2000	2	SSG	69	26.4	4.8	465.8
22	500	5	SSG	67	41.1	12.1	476.1
23	1250	5	SSG	79	44.1	12.3	479.3
24	2000	5	SSG	66	49.0	11.7	480.2
25	500	8	SSG	76	68.6	25.7	489.3
26	1250	8	SSG	88	69.2	25.6	491.7
27	2000	8	SSG	70	71.1	27.4	493.2
28	1250	5	CS	76	80.1	30.1	478.6
29	1250	5	KC	82	64.4	35.6	479.8
30	1250	5	SSG	83	48.8	26.1	476.5

^aNot applicable

Abbreviations: S-SuSMEDDS, solidified supersaturable self-microemulsifying drug delivery system; CSR, critical solidifying ratio; D₁₅, percentage of drug released in 15 min; Disint%, percentage of disintegration in 30 min; DE, dissolution efficiency; CS, croscarmellose sodium; KC, Kollidon^® CL; SSG, Sodium starch glycolate.