Table 5. Experimental and predicted values for the optimized S-SuSMEDDS granules and tablets.
| Type | Composition | Response | Importance | Predicted value | Experimental value | Percentage prediction errora |
|---|---|---|---|---|---|---|
| Optimized S-SuSMEDDS granules | X1: 53% | Y1 (mL/100 g) | + | 1.07 | 1.0 ± 0.2 | -7.0 |
| X2: 47% | Y2 (%) | + | 54.6 | 58.6 ± 2.2 | 6.8 | |
| Optimized S-SuSMEDDS tablets | X1: 536 kgf | Y1 (N) | - | 73.4 | 76.6 ± 3.5 | 4.2 |
| X2: 6.9% | Y2 (%) | ++ | 98 | 94.3 ± 5.6 | -3.8 | |
| X3: CS | Y3 (%) | +++ | 36.1 | 38.5 ± 1.8 | 6.2 | |
| Y4 (mg) | + | 485.8 | 489.4 ± 2.6 | 0.7 |
aCalculated using the formula ([experimental value - predicted value]/experimental value) × 100 (%). Values are presented as the mean ± SD (n = 3).
Abbreviations: S-SuSMEDDS, solidified supersaturable self-microemulsifying drug delivery system; CS, croscarmellose sodium.