Table 2. Univariate and multivariate analysis of prognostic factor associated with overall survival (OS).
| Factor | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| OS, median (95% CI), months | p value* | HR | (95% CI) | p value† | ||
| Gender | Male | 11.3 (9.1-13.4) | 0.809 | - | - | NS |
| Female | 9.9 (5.9-13.9) | - | - | |||
| Age (years) | < 60 | 10.3 (8.3-12.4) | 0.732 | - | - | NS |
| ≥ 60 | 12.2 (9.8-14.7) | |||||
| ECOG PS | 0-1 | 11.4 (9.7-13.0) | 0.116 | - | - | NS |
| 2-3 | 5.5 (2.2-8.8) | |||||
| Etiology of LC | HBV | 9.1 (7.2-10.9) | 0.012 | - | - | NS |
| Others | 14.6 (12.0-17.3) | - | - | |||
| Child-Pugh classification | A | 12.3 (10.4-14.2) | < 0.001 | 1.000 | - | |
| B | 5.5 (3.0-8.0) | 2.590 | (1.707-3.929) | < 0.001 | ||
| AFP (ng/mL) | < 400 | 13.2 (11.2-15.2) | < 0.001 | 1.000 | - | |
| ≥ 400 | 6.8 (5.3-8.3) | 1.726 | (1.208-2.467) | 0.003 | ||
| Vascular invasion | No | 12.2 (9.1-15.3) | 0.010 | - | - | |
| Yes | 9.9 (7.9-11.9) | - | - | NS | ||
| Status of intrahepatic tumor | Controlled | 14.6 (12.6-16.7) | < 0.001 | 1.000 | - | |
| Uncontrolled | 6.4 (4.9-7.9) | 3.037 | (2.170-4.251) | < 0.001 | ||
| Synchronicity of metastatic LN | No | 13.2 (10.9-15.6) | < 0.001 | - | - | |
| Yes | 6.2 (4.4-7.9) | - | - | NS | ||
| Size of metastatic LN (cm) | < 3 | 15.6 (11.5-19.6) | < 0.001 | - | - | |
| ≥ 3 | 7.9 (6.4-9.3) | - | - | NS | ||
| No. of metastatic LN | 1 | 15.6 (11.2-20.0) | < 0.001 | 1.000 | - | |
| 2 | 12.5 (7.9-17.2) | 1.220 | (0.778 -1.914) | 0.386 | ||
| ≥ 3 | 7.8 (6.1-9.5) | 1.832 | (1.274-2.636) | 0.001 | ||
| Location of metastatic LN | Regional | 13.3 (10.7-15.9) | < 0.001 | 1.000 | - | |
| Non-regional | 7.1 (5.7-8.5) | 1.889 | (1.368-2.608) | < 0.001 | ||
| Distant metastasis | Absent | 11.8 (10.0-13.6) | < 0.001 | 1.000 | - | |
| Present | 7.7 (4.2-11.2) | 1.752 | (1.223-2.509) | 0.002 | ||
| Previous treatment | No | 5.5 (0.0-18.0) | 0.303 | - | - | |
| Yes | 11.1 (9.5-12.8) | - | - | NS | ||
| Concurrent sorafenib | No | 11.6 (9.7-13.6) | 0.058 | - | - | NS |
| Yes | 5.2 (4.2-6.2) | - | - | |||
| Post-RT treatment | No | 8.5 (6.1-10.8) | 0.723 | - | - | NS |
| Yes | 11.6 (9.7-13.6) | - | - | |||
| LN response | Responder | 14.2 (11.6-16.8) | < 0.001 | 1.000 | - | |
| Non-responder | 7.5 (6.1-8.9) | 2.391 | (1.741-3.282) | < 0.001 | ||
Abbreviations: CI, confidence interval; HR, Hazard Ratio; NS, not significant; Responder, complete or partial response; Non-responder, stable or progressive disease; all other abbreviations as in Table 1
*log-rank test
†Cox proportional hazards model.