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. 2017 Oct 10;8(55):94619–94634. doi: 10.18632/oncotarget.21816

Figure 1. LY2510924 peptide and LY2624587 antibody inhibition of SDF-1/CXCR4 binding in human, monkey, and mouse cells.

Figure 1

LY2510924 (peptide antagonist) inhibits binding in (A) human, (B) monkey, and (C) mouse cells. LY2624587 (CXCR4 mAb) inhibits binding in (D) human, (E) monkey, and (F) mouse cells. Human cells = leukemia CCRF-CEM cells with high-level expression of human CXCR4, monkey cells = MDA-MB-435 cells stably transfected with monkey CXCR4, and mouse cells = 2PK-3 lymphoma cells with high-level expression of mouse CXCR4. Ki = inhibitor constant.