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. 2017 Oct 16;8(55):94726–94737. doi: 10.18632/oncotarget.21886

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Copyright: © 2017 Li et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Cordycepin (Cpn) regulated intracellular cholesterol homeostasis by inhibiting cholesterol uptake (A), promoting cholesterol efflux (B) and modulating mRNA levels of genes that involved in cholesterol uptake (C) and efflux (D) in RAW264. 7 macrophages. Values are means ± SEM of at least three experiments. ^###p < 0.001, vehicle vs. blank, *p < 0.05, **p < 0.01, ***p < 0.001, test group vs. vehicle group. SR-A/B, scavenger receptors A/B; CD36, cluster of differentiation 36; PPARγ, peroxisome proliferator-activated receptor γ; LXRα, liver X receptor α; ABCA1/G1, ATP-binding cassette transporters A1/G1.