Table 3. The level of p16, RASSF1A gene methylation and the risk of lung cancer.
| The level of gene methylation (%) | Lung cancer group | Control group | OR (95%CI)* | P* | |
|---|---|---|---|---|---|
| P16 is classified by quartile | First quartile | 35 | 65 | 1 | — |
| Second quartile | 52 | 48 | 1.856 (1.018∼3.382) | 0.043 | |
| Third quartile | 57 | 44 | 2.310 (1.270∼4.202) | 0.006 | |
| Fourth quartile | 56 | 43 | 2.079 (1.140∼3.791) | 0.017 | |
| P** | 0.006 | — | — | ||
| P trend | — | — | 0.002 | — | |
| P16 is classified by median | ≤Median | 87 | 113 | 1 | — |
| >Median | 113 | 87 | 1.597 (1.052∼2.422) | 0.028 | |
| P** | 0.009 | — | — | ||
| RASSF1A is classified by quartile | First quartile | 38 | 62 | 1 | — |
| Second quartile | 50 | 49 | 1.492 (0.822∼2.708) | 0.189 | |
| Third quartile | 58 | 43 | 1.976 (1.088∼3.591) | 0.025 | |
| Fourth quartile | 54 | 46 | 1.837 (1.013∼3.333) | 0.045 | |
| P** | 0.035 | — | — | ||
| P trend | — | — | 0.014 | — | |
| RASSF1A is classified by median | ≤Median | 88 | 111 | 1 | — |
| >Median | 112 | 89 | 1.551 (1.023∼2.353) | 0.039 | |
| P** | 0.021 | — | — | ||
ps: * is used unconditional Logistic regression to calculate OR and P values, Adjusted by gender, age, smoking status; ** is the result of x2.