Table 1. Clinical summary of included studies.
| Author/Year | Country | Ethnicity | Age group | Patient group | Sepsis type | Subjects | SNP method | Sepsis risk reported | Septic shock risk reported | Mortality reported |
|---|---|---|---|---|---|---|---|---|---|---|
| Allam et al. 2015* | Saudi Arabia | Asian | Neonate | NICU | S | 137 | Taqman | Y | N | N |
| Cardoso et al. 2015* | Brazil | Mixed | ≥ 18 | ICU | S,SS, SSH | 72 | Taqman | N | N | Y |
| Feng et al. 2015* | China | Asian | NA | Pneumonia | SS, SSH | 277 | Taqman | N | N | Y |
| Gupta et al. 2015* | India | Asian | ≥ 16 | Trauma | S | 114 | PCR-SSP | Y | N | N |
| Baghel et al. 2014* | India | Asian | ≥ 18 | Post-operative | S | 239 | PCR | Y | N | N |
| Kothari et al. 2013* | India | Asian | NA | Critical ill patient | S, SSH | 400 | PCR | Y | Y | N |
| Susantitaphong et al. 2013* | USA | Mixed | ≥ 18 | AKI | S | 262 | PCR | Y | N | N |
| Azevedo et al. 2012* | Brazil | Mixed | < 18 | PICU patients | S,SS, SSH | 1003 | Taqman | Y | N | Y |
| Song et al. 2012* | China | Asian | NA | Trauma and Critical ill patient | S,SS | 1402 | PCR | Y | N | Y |
| Duan et al. 2011* | China | Asian | ≥ 18 | Trauma | S | 305 | PCR-RFLP | Y | N | N |
| Härtel et al. 2011* | Germany | Mixed | Infant | VLBWI | S | 2870 | PCR | Y | N | N |
| Paskulin et al. 2011* | Brazil | Caucasian | ≥ 18 | Critical ill patient | S, SSH | 520 | PCR-RFLP | Y | Y | Y |
| Carregaro et al. 2010 * | Brazil | Mixed | ≥ 18 | ICU patients | S,SS, SSH | 303 | Taqman | Y | N | N |
| Gu et al. 2010* | China | Asian | ≥ 18 | Trauma | S | 305 | PCR | Y | N | N |
| Menges et al. 2008 | Germany | Caucasian | ≥ 18 | Trauma | S | 230 | PCR | Y | N | N |
| Jessen et al. 2007 | Denmark | Caucasian | ≥ 17 | Gram negative | S,SS, SSH | 304 | PCR | N | N | Y |
| McDaniel et al. 2007 | USA | Mixed | NA | Trauma | S | 68 | PCR | Y | N | N |
| Garnacho-Montero et al. 2006 | Spain | Caucasian | > 18 | ICU | S,SS, SSH | 325 | PCR | Y | Y | Y |
| Schueller et al. 2006 | Germany | Caucasian | < 32 weeks | Premature infant | S | 169 | PCR | Y | N | N |
| Sipahi et al. 2006 | Turkey | Caucasian | < 15 | Critical ill patient | SS | 130 | PCR | Y | N | Y |
| Nakada et al. 2005 | Japan | Asian | NA | Critical ill patient | S | 411 | PCR-RFLP | Y | N | Y |
| Gordon et al. 2004 | UK and Australia | Caucasian | ≥ 18 | ICU patient | SS, SSH | 566 | PCR-RFLP, PCR-SSP | Y | N | Y |
| Jaber et al. 2004 | USA | Caucasian | ≥ 18 | ARF | S | 61 | PCR-SSP | Y | N | N |
| Balding et al. 2003 | Ireland | Caucasian | < 16 | Meningococaemia | S | 572 | PCR | Y | N | Y |
| Calvano et al. 2003 | Spain | Mixed | > 21 | Post-operative | S, SSH | 44 | PCR | Y | Y | Y |
| Schaaf et al. 2003 | Germany | Caucasian | NA | Pneumococcal infection | S,SS, SSH | 118 | PCR | Y | Y | Y |
| Treszl et al. 2003 | Hungary | Caucasian | Infant | LBWI | S | 103 | PCR-RFLP | Y | N | N |
| Zhang et al. 2003 | China | Asian | NA | ASP | SSH | 148 | PCR | Y | Y | N |
| Zhang et al. 2003 | China | Asian | NA | ABP | SSH | 120 | PCR | Y | Y | N |
| Majetschak et al. 2002 | Netherlands | Caucasian | ≥ 18 | Trauma | SS | 70 | PCR | Y | N | N |
| Appoloni et al. 2001 | Belgium | Caucasian | NA | ICU patient | SSH | 34 | PCR | N | N | Y |
| Waterer et al. 2001 | Australia | Mixed | NA | CAP | S | 280 | PCR | Y | N | Y |
| Mira et al. 1999 | France | Caucasian | NA | ICU patient | SSH | 176 | PCR | Y | Y | Y |
| Nuntayanuwat et al. 1999 | Thailand | Asian | NA | Meliodosis | S | 146 | PCR-RFLP | Y | N | N |
ABP: Acute biliary pancreatitis; AKI: Acute kidney injury; ARF: Acute renal failure; ASP: Acute severe pancreatitis; CAP: Community acquired pneumonia; ICU : Intensive care unit; LBWI: Low birth weight infant; NA: Not available; PCR: Polymerase Chain Reaction; PCR-RFLP: Polymerase chain reaction-restriction fragment length polymorphism; PCR-SSP: Polymerase chain reaction -sequence-specific amplification; PICU: Pediatric intensive care unit; S: Sepsis; SS: Severe sepsis; SSH: Septic shock; N: No; Y: Yes; VLBWI: Very Low birth weight infant; *: Studies which were newly included in the review when compare with previous meta-analysis.